Characterization of myelin-containing fractions from normal and DM20 transgenic mouse brain

a developmental study.
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National Library of Canada , Ottawa
SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL17247698M
ISBN 100612020541
OCLC/WorldCa46512149

Characterization of myelin fractions from human brain white matter.

Details Characterization of myelin-containing fractions from normal and DM20 transgenic mouse brain PDF

Cruz TF, Moscarello MA. Myelin and myelin-containing (P3) fractions were prepared from human white matter by discontinuous sucrose gradient centrifugation.

The myelin isolated from each of the fractions of different densities was morphologically and biochemically by: The mRNA of SDR12, also referred to as FLJ, has been shown to be present in human white matter in the cerebral cortex, while its existence at protein level still remains hypothetical (Morris.

Request PDF | Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide | Insulation by myelin lipids is essential. Request PDF | Mice with Conditional Inactivation of Fibroblast Growth Factor Receptor-2 Signaling in Oligodendrocytes Have Normal Myelin But Display Dramatic Hyperactivity when Combined with Cnp1.

The pathological hallmark of multiple sclerosis (MS) is myelin phagocytosis.

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It remains unclear why microglia and macrophages demyelinate axons in MS, but previously found or yet-unknown changes in the myelin of MS patients could contribute to this process. We therefore studied whether myelin from normal-appearing white matter (NAWM) of MS donors is phagocytosed more efficiently Cited by: The MBP gene, distributed over a kbp region of chromosome 18 in the mouse, comprises seven exons, of which three (exons 2, 5 and 6) are alternatively spliced, accounting for all five forms of mouse MBP identified in the CNS (De Ferra et al.,Roach et al.,Takahashi et al.,Newman et al., ).

The transcript corresponding Cited by: It occurs at doses greater than 1, to 1, neurorets (equivalent to 6, cGy given in 30 fractions for 6 weeks, a treatment commonly used for primary brain tumors).